Fluconazole: Pharmacology, Clinical Uses and Health Effects by Santiago Herrera, Joaquin Acosta

By Santiago Herrera, Joaquin Acosta

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Additional resources for Fluconazole: Pharmacology, Clinical Uses and Health Effects

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Aoyama T, Hirata K, Hirata R, Yamazaki H, Yamamoto Y, Hayashi H, et al. Population pharmacokinetics of fluconazole after administration of fosfluconazole and fluconazole in critically ill patients. Journal of clinical pharmacy and therapeutics. 2012;37(3):356-63. Baddley JW, Patel M, Bhavnani SM, Moser SA, Andes DR. Association of fluconazole pharmacodynamics with mortality in patients with candidemia. Antimicrobial agents and chemotherapy. 2008;52(9): 3022-8. Pai MP, Turpin RS, Garey KW. Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia.

2003). , 2003; Jin & Lin, 2005; Pressler, 2012). Anecdotally, treatment success rate is approximately 50%, with an increased likelihood of cure if predisposing factors can be controlled or eliminated (Pressler, 2012). The majority of fungal urinary tract isolates in dogs and cats are C. albicans, although other species of Candida such as C. parapsilosis, C. tropicalis, C. glabrata, and C. krusei have also been reported (Jin & Lin, 2005; Pressler, 2012). To the authors’ knowledge, successful treatment of disseminated candidiasis with fluconazole has not been described in dogs or cats.

Clark and Marcella D. Ridgway become limiting, especially for large dogs, and may be a determining factor in an owner’s decision whether or not to continue treatment. Both cost and administration-related factors may also play a role in the choice of fluconazole for treatment of coccidioidomycosis in other animals. , 2006). , 2006). , 1990). , 1990). Later, compounded fluconazole was employed to treat pulmonary coccidioidomycosis in two adult horses, with measurement of plasma drug concentrations to ensure appropriate exposure.

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