Computational Neuroscience: A Comprehensive Approach by Jianfeng Feng

By Jianfeng Feng

How does the mind paintings? After a century of study, we nonetheless lack a coherent view of the way neurons strategy indications and regulate our actions. yet because the box of computational neuroscience maintains to adapt, we discover that it offers a theoretical origin and a suite of technological methods which can considerably increase our understanding.

Computational Neuroscience: A complete strategy presents a unified therapy of the mathematical idea of the anxious method and offers concrete examples demonstrating how computational innovations can light up tough neuroscience difficulties. In chapters contributed via most sensible researchers, the ebook introduces the elemental mathematical recommendations, then examines modeling in any respect degrees, from single-channel and unmarried neuron modeling to neuronal networks and system-level modeling. The emphasis is on versions with shut ties to experimental observations and knowledge, and the authors assessment program of the versions to structures similar to olfactory bulbs, fly imaginative and prescient, and sensorymotor systems.

Understanding the character and bounds of the techniques neural structures hire to approach and transmit sensory info stands one of the most fun and tough demanding situations confronted through glossy technological know-how. This e-book sincerely exhibits how computational neuroscience has and may proceed to assist meet that problem.

Show description

Read Online or Download Computational Neuroscience: A Comprehensive Approach (Chapman & Hall/CRC Mathematical & Computational Biology) PDF

Best physical books

Readings in Qualitative Reasoning About Physical Systems

Readings in Qualitative Reasoning approximately actual platforms describes the automatic reasoning in regards to the actual international utilizing qualitative representations. this article is split into 9 chapters, each one concentrating on a few point of qualitative physics. the 1st bankruptcy take care of qualitative physics, that is thinking about representing and reasoning concerning the actual international.

Neural Stem Cell Assays

Together with an outline of development made within the box during the last decade, Neural Stem cellphone Assays offers a close and finished evaluate of the elemental equipment for neural stem phone cultures. This one-stop reference for constant equipment and trustworthy instruments spans the whole assay paintings movement, from isolation or iteration of neural stem cells to characterization, manipulation and ultimate software of NSCs in sickness paradigms, corresponding to Parkinson's sickness, a number of sclerosis, and ALS.

A Companion to Dental Anthropology

Spouse to Dental Anthropology offers a set of unique readings addressing all elements and sub-disciplines of the sphere of dental anthropology—from its origins and evolution via to the most recent medical learn. Represents the main finished assurance of all sub-disciplines of dental anthropology on hand this present day positive aspects person chapters written by means of  specialists of their particular zone of dental examine contains authors who additionally current effects from their examine via case reports or voiced reviews approximately their paintings deals large insurance of subject matters on the subject of dental evolution, morphometric version, and pathology

Extra info for Computational Neuroscience: A Comprehensive Approach (Chapman & Hall/CRC Mathematical & Computational Biology)

Sample text

Because of the central role of many ion channels in cell physiology, ion channels are also major targets for drugs and drug development. The basic function of ion channels is simple: they conduct ions. Broadly speaking, ion channels have three fundamental properties: 1. Conductance, or current-voltage relationships at specific conditions. These relationships can be almost linear, but they can also show features such as saturation and rectification (preferential current in one direction), and they can show very complex behaviour in the presence of multiple types of ions.

F. (2001). Optimally decoding the input rate from an observation of the interspike intervals. J. Phys. A. 34: 7475-7492. F. (2001). Is the integrate-and-fire model good enough? – a review. Neural Networks 14: 955-975. F. (2003). Effects of correlated and synchronized stochastic inputs to leaky integrator neuronal model. J. Theore. Biol: in press. , and Li, G. (2000). Synchronization due to common pulsed input in Stein’s model. Phys. Rev. E, 61: 2987-2995. , and Li, G. (2002). Impact of geometrical structures on the output of neuronal models – a theoretical and numerical analysis.

When a >> e + 1, E[T ] ≈ TR + ln a e2 1 1 − 2 , − 2 a −1 4 (a − 1) a 1 e2 1 − 2 . 2 2 (a − 1) a These results show clearly how small noise reduces the mean interspike interval. Steady state well below threshold. When a << 1 − e , the expectation of the interspike interval is √ (1 − a )2 e p exp E[T ] ≈ TR + , 1−a e2 and the variance is 2(1 − a )2 e 2p exp , Var[T ] ≈ (1 − a )2 e2 Many other results are given in the aforementioned reference, which includes an exhaustive study of the dependence of the coefficient of variation of T on the input parameters.

Download PDF sample

Rated 4.15 of 5 – based on 5 votes