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The in vivo multi-electrode probe community is also helping to advance the state of the art, since they share many of the same hardware and data analysis problems with the in vitro community. 4 MEA fabrication MEAs consist of a number of cell-sized electrodes (10-100 Ixm) arrayed across the bottom of a cell culture dish. The substrate is usually glass, with leads made of gold or the transparent conductor indium-tin oxide, that carry signals from electrodes to external electronics, and carry stimuli to the electrodes (Fig.
Fig. 9. Signal flow diagram for Model II. Matching PDC calculations using simulated rather than theoretical values are shown in Fig. 12. According to PDC, Xl (n)'s role as a signal source for the whole structure is equally well deducible. A question that can arise about the use of PDC regards what happens when calculations are based on the processing of a reduced number of structures than are actually representative of the structure and dynamics of the process. e. by computing the pairwise PDC of the pairs like (xl(n), x2(n)), (x3(n), xa(n)) and (xs(n), x 6 ( n ) ) without making joint calculations involving the other structures.
And Sameshima, K. (2001) Partial directed coherence a new concept in neural structure determination. Biol. , in press. , Yu, C. and Oshiro, M. (1991) Structural analysis of neural circuits using the theory of directed graphs. Comp. Biomed. , 24: 7-28. C. and Timo-Iaria, C. 0998) Studying the interaction between brain structures via directed coherence and Granger causality. Appl. Sig. , 5: 40-48. S. G. (1986) Random Data: Analysis and Measurement Procedures. John Wiley, New York, 2nd ed. Brunel, N.